Inicio » Eventos » Congresos SEMA » 2023 EEMGS/SEMA » PROGRAMME EEMGS/SEMA 2023


51st European Environmental Mutagenesis and Genomics Society (EEMGS) & 27th Spanish Environmental Mutagenesis and Genomics Society (SEMA) meeting

HESI workshop «Quantitative Interpretation of Genetic Toxicity Dose-response Data for Risk Assessment and Reg Decision-making«

MÁLAGA (Spain)
May 15th-18th, 2023


HESI Workshop

Quantitative Interpretation of Genetic Toxicity Dose-response Data for Risk Assessment and Regulatory Decision-making – State of the Science, Applications, and Persistent Challenges

Andreas Zeller (Roche), George Johnson (Swansea University), Paul White (Health Canada)
on behalf of the HESI GTTC

HESI WorkshopMonday 15th May: 9:00 - 15:00
(Forum 2)
8:00 - 9:00Registration & Breakfast
Quantitative Dose-response Analyses: State of the Science
9:00 - 9:10Welcome & Overview of Workshop Goals
Co-chairs: Andreas Zeller (Roche, SWITZERLAND), George Johnson (Swansea University, UK), Paul White (Health Canada, CANADA)
9:10 - 9:40Quantitative Interpretation of In Vivo Mutagenicity Dose Response Data for Risk Assessment and Regulatory Decision-Making
Paul White (Health Canada, CANADA) & Stefan Pfuhler (Procter and Gamble, USA)
9:40 - 10:10The interpretation of in vitro dose-response data for risk assessment and regulatory decision-making
Marc Beal (Health Canada, CANADA)
10:10 - 10:40Guided Discussion
10:40 - 11:10Coffee Break
Application of Quantitative Data Interpretation to Pharmaceutical Impurities
11:10 - 11:40Nitrosamine impurity issues and potential resolutions
George Johnson (Swansea University, UK)
11:40 - 12:10In vivo genetic toxicity assessments for nitrosamines
Maik Schuler (Pfizer, USA) or Shaofei Zhang (Pfizer, USA)
12:10 - 12:40Defining a NOGEL for mutation induction in Muta™Mouse following exposure to N-Nitrosodimethylamine (NDMA)
Anthony Lynch (GlaxoSmithKline, UK)
12:40 - 13:40Lunch
13:40 - 14:10Regulatory considerations related to mutagenic impurities in pharmaceuticals
Roland Frotschl (BfArM, GERMANY)
14:10 - 14:50Guided Discussion
14:50 - 15:00Concluding Remarks

15:00 – 15:30

15:30 – 16:00
Open Ceremony

16:00 – 17:00
RNA-mediated genome instability and transcription-replication conflicts
Andrés Aguilera (Keynote Speaker)
(University of Seville, SPAIN)

Session 01:
EEMGS New Investigators (EEMGS NI)
Monday 15th May
17:00 - 18:30
(Forum 2)
Chairs: Fiona Chapman (Imperial Brands, UK) & Julen Sanz (Vrije Universiteit Brussel, BELGIUM)
17:00 - 17:30Helena Reinardy (Invited Speaker)
(Scottish Association for Marine Science) UK
A journey in pursuit of marine genetic toxicology
17:30 - 17:45Julie Sanders
(Sciensano) BELGIUM
Mixtures of genotoxicants: does the principle of additivity applies?
17:45 - 18:00Axel Rosendahl Huber
(IRB Barcelona) SPAIN
Estimating the mutation risks conferred by mutational processes
18:00 - 18:15Demi Pritchard
(Swansea University) UK
Negative data is still useful data: investigating and detecting non-genotoxic carcinogens in vitro
18:15 - 18:30Alba García-Rodríguez
(Autonomous University of Barcelona) SPAIN
Modeling human-derived in vitro barriers for environmental toxicology

19:30 – 21:00
Welcome Reception

El Merendero de Antonio Martín

Pl. de la Malagueta, 4, 29016 Málaga

Session 02:
International Workshops on Genotoxicity Testing (IWGT)
Tuesday 16th May
9:00 - 11:00
(Forum 1)
Chairs: Andreas Zeller (Roche, SWITZERLAND) & Hans-Joerg Martus (Novartis, SWITZERLAND)
9:00 - 9:30Mirjam Luijten (Invited Speaker)
(National Institute for Public Health and the Environment) THE NETHERLANDS
Evaluation of the Standard Battery of In Vitro Genotoxicity Tests for Human Health Risk Assessment through Mathematical Modelling: A Report of the International Workshop on Genotoxicity Testing (IWGT)
9:30 - 10:00Carol Beevers
(Corteva Agriscience) UK
In Vivo Genotoxicity Testing Strategies: Report of the International Workshop on Genotoxicity Testing (IWGT)
10:00 - 10:30Stephen Dertinger
(Litron Laboratories) USA
Assessing the Quality and Making Appropriate Use of Historical Negative Control Data: A Report of the International Workshop on Genotoxicity Testing (IWGT)
10:30 - 11:00Hans-Joerg Martus
Summary of 8th IWGT in Ottawa, Canada
Session 03:
New Approach Methodologies (NAMs)
Tuesday 16th May
9:00 - 11:00
(Forum 2)
Chairs: Guillermo Repetto (Universidad Pablo de Olavide de Sevilla, SPAIN) & Isabel Gaivão (Universidade de Trás-os-Montes e Alto Douro, PORTUGAL)
9:00 - 9:45Francesca Caloni (Invited Speaker)
(University of Milan) ITALY
3Rs: from complexity to predictivity
9:45 - 10:00Ludovic Le Hégarat
(French Agency for Food, Environmental and Occupational Health & Safety - Fougeres Laboratory, Toxicology of Contaminants Unit) FRANCE
The human HepaRG cell line: a brief history of its use in genetic toxicology: advantages, limits and future directions
10:00 - 10:15Julia Catalán
(Finnish Institute of Occupational Health) FINLAND
In vitro cell transforming capacity of different types of nano-plastics
10:15 - 10:30Elsje Burgers
(Division of Drug Discovery and Safety, Leiden Academic Centre for Drug Research - Leiden University) THE NETHERLANDS
In silico modelling of crosstalk between DNA damage and oxidative stress for prediction of cellular adversity
10:30 - 10:45Lieselot Hemeryck
(Laboratory of Integrative Metabolomics, Ghent University) BELGIUM
Perspectives for DNA adductomics in large-scale exposomics: upscaling sample preparation and preprocessing data
10:45 - 11:00Ann-Karin Olsen
(Norwegian Institute of Public Health, Division of Climate and Environmental Health) NORWAY
Oxidative Stress Disrupt Differentiation of Human Induced Pluripotent Stem Cells

11:00 – 11:30
Coffee Break

Session 04:
International Comet Assay Working Group (ICAWG)
Tuesday 16th May
11:30 - 13:00
(Forum 1)
Chairs: Goran Gajski (Institute for Medical Research and Occupational Health, CROATIA) & Amaya Azqueta (Universidad de Navarra, SPAIN)
11:30 - 12:00Bojana Žegura (Invited Speaker)
(Department of Genetic Toxicology and Cancer Biology, National Institute of Biology) SLOVENIA
Advanced 3D cell models and zebrafish embryos: A bridge between in vitro and in vivo
12:00 - 12:15Mugimane Manjanatha
(Division of Genetic and Molecular Toxicology, US FDA, National Center for Toxicological Research) USA
Utility of 3D HepaRG spheroid model for testing genotoxicity using high-throughput CometChip platform
12:15 - 12:30Miguel Collía
(Department of Pharmacology and Toxicology, School of Pharmacy and Nutrition, Universidad de Navarra) SPAIN
Use of the CometChip® for the in vitro, in vivo and Fpg-modifed assay
12:30 - 12:45Lada Zivkovic
(Department of Pathobiology, Faculty of Pharmacy, University of Belgrade) SERBIA
Evaluation of antioxidative, antigenotoxic, and anticancer activities of commercial medical mushrooms products: Agaricus blazei, Cordyceps Sinensis and Immune Assist
12:45 - 13:00Vanessa Andrade
(Laboratory of Translational Biomedicine, Graduate Program of Health Sciences, University of Southern Santa Catarina – UNESC) BRAZIL
Maternal exercise during pregnancy modulates genetic and biochemical damage caused by high consumption of fructose in offspring
Session 05:
Tuesday 16th May
11:30 - 13:00
(Forum 2)
Chairs: Awadhesh Jha (University of Plymouth, UK) & Óscar Herrero (Universidad Nacional de Educación a Distancia, SPAIN)
11:30 - 12:15Marinella Farré (Invited Speaker)
(Institute of Environmental Assessment and Water Research) SPAIN
The challenge of assessing contaminants of emerging concern and microplastics
12:15 - 12:30Awadhesh N. Jha
(School of Biological and Marine Sciences, University of Plymouth) UK
Assessing the Impact of Persistent and Emerging Contaminants on Aquatic Organisms
12:30 - 12:45Fengjia Liu
(The Scottish Association for Marine Science) UK
Hydrogen peroxide-induced oxidative damage in sea urchin (Paracentrotus lividus) DNA
12:45 - 13:00Mujo Hasanović
(University of Sarajevo - Institute for Genetic Engineering and Biotechnology) BOSNIA & HERZEGOVINA
Plant comet assay in biomonitoring of air pollution in Sarajevo, Bosnia and Herzegovina

13:00 – 14:00

Pitch-poster Presentation 1Tuesday 16th May
14:00 - 14:30
(Forum 2)
14:00 - 14:05Carina Ladeira
(Health & Technology Research Center, Escola Superior de Tecnologia da Saúde) PORTUGAL
Blood molecular profile to predict genotoxicity from exposure to antineoplastic drugs – a comparison with cytokinesis-block micronucleus assay results
14:05 - 14:10Alonso Rodríguez Pescador
(University of Oviedo) SPAIN
Internalization, toxicity, and genotoxicity of ultra-small non-magnetic iron oxide (III) nanoparticles in cultured cell lines and Drosophila larvae in vivo
14:10 - 14:15Michaela Blažíčková
(Biomedical Research Center) SLOVAKIA
Determination of proliferation and genotoxic effect of thymol and acetyl thymol on in vitro intestinal model
14:15 - 14:20Sharleen Friese
(DUniversity of Potsdam) GERMANY
Variations of Dietary Trace Element Supply and its Consequences on Genomic Stability in the Murine Cerebellum
14:20 - 14:25Aliro Villacorta
(Universidad Arturo Prat) CHILE
A new source of representative secondary PET nanoplastics. Obtention, characterization, and hazard evaluation
14:25 - 14:30Anastasiya Mircheva
(Department of Pharmacology and Toxicology, Maastricht University) THE NETHERLANDS
Investigation of base excision repair and oxidative stress in preeclampsia-complicated placentas – a pilot study

14:30 – 16:00
Poster Session 1 & Sponsor Visit
(while coffee is served)

16:00 – 17:00
Chromosome instability, DNA repair deficiency and cancer: insights from Fanconi anemia
Jordi Surrallés (Keynote Speaker)
(Santa Creu i Sant Pau Hospital Research Institute Foundation, SPAIN)

18:30 – 20:30
Social Event

Plaza de la Merced

(meeting point)

Session 06:
Wednesday 17th May
9:00 - 11:00
(Forum 1)
Chairs: Roland Frötschl (BfArM, GERMANY) & Bennard van Ravenzwaay (Environmental Sciences Consulting, GERMANY)
9:00 - 9:15Bennard van Ravenzwaay (Invited Speaker)
(Environmental Sciences Consulting) GERMANY
An Introduction to ECETOC’s workshops on Point of Departure and IVIVE modelling
9:15 - 9:40Stephan Schaller
Physiologically Based Kinetic Modelling applications in Chemical Risk Assessment
9:40 - 10:05Richard Currie
(Syngenta International Research Center) UK
Applying transcriptomic benchmark modelling for toxicological decision making
10:05 - 10:30Franziska Zickgraf
Determination of point of departures based on high throughput in vitro metabolomics
10:30 - 10:50Tim Gant
(UK Health Security Agency) UK
Summary of the ECETOC workshop from IVIVE to PODS – translating research methods to application
10:50 - 11:00General Discussion
Session 07:
DNA Repair, Chromatin Structure and Genome Stability
Wednesday 17th May
9:00 - 11:00
(Forum 2)
Chairs: María Teresa Roldán (Universidad de Córdoba, SPAIN) & Luisa María Sierra (Universidad de Oviedo, SPAIN)
9:00 - 9:45Haico van Attikum (Invited Speaker)
(Leiden University Medical Center) THE NETHERLANDS
Specific killing of BRCA1-deficient cancer cells by depletion of EXO1
9:45 - 10:00Marina Jordano Raya
(University of Córdoba) SPAIN
Influence of orphan base and sequence context on the processing of AP sites by AP lyases in Arabidopsis thaliana
10:00 - 10:15Helga Stopper
(Institute of Pharmacology and Toxicology, University of Wuerzburg) GERMANY
Role of Phosphatase and Tensin homolog (Pten) in Insulin mediated DNA damage
10:15 - 10:30Thomas G. Hofmann
(Institute of Toxicology, Johannes Gutenberg University of Mainz) GERMANY
A direct role for HIPK2 in homology-directed DNA repair and the regulation of PARP inhibitor sensitivity
10:30 - 10:45Ana Rita Guedes
(CECAV– Centro de Ciência Animal e Veterinária, Universidade de Trás-os-Montes e Alto Douro) PORTUGAL
Could DNA damage be a useful biomarker of diagnosis and prognostic in human breast and colorectal cancer?
10:45 - 11:00Bernd Kaina
(Institute of Toxicology, University Medical Center, Mainz) GERMANY
Senescence and cell death triggered by the DNA alkylation damage O6-methylguanine

11:00 – 11:30
Coffee Break

Session 08:
Machine Learning
Wednesday 17th May
11:30 - 13:00
(Forum 1)
Chairs: George Johnson (Swansea University, UK)
11:30 - 12:00Steve Bryce
(Litron Labs) USA
Introduction to Machine Learning in Genetic Toxicology
12:00 - 12:30Paul Rees (Invited Speaker)
(Swansea University) UK
Deep Neural Networks to Automate Scoring Of The Imaging Flow Cytometry In-Vitro Micronucleus Assay
12:30 - 13:00Joost Beltman
(Leiden University) THE NETHERLANDS
Towards a quantitative understanding of the DNA damage response through data-driven dynamical modeling
Session 09:
New Challenges In Genotoxicity Assessment
Wednesday 17th May
11:30 - 13:00
(Forum 2)
Chairs: Ricard Marcos (Universitat Autònoma de Barcelona, SPAIN) & Vanessa Valdiglesias (Universidade da Coruña, SPAIN)
11:30 - 12:15Alba Hernández (Invited Speaker)
(Autonomous University of Barcelona) SPAIN
Understanding the health risks of exposure to micro- & nano-plastics
12:15 - 12:30Massimo Aloisi
(University of L’Aquila) ITALY
Biological effects of chronic oral exposure to polystyrene nanoparticles in Drosophila melanogaster
12:30 - 12:45Jolanta Kwasniewska
(University of Silesia Institution in Katowice) POLAND
Recent achievements in micronuclei characterization
12:45 - 13:00Maricel Marin-Kuan
(Nestlé Research, Vers-chez-les-Blancs) SWITZERLAND
Novel methodology to assess genotoxicity in Food Contact Materials (FCM)

13:00 – 14:00

Pitch-poster Presentation 2Wednesday 17th May
14:00 - 14:30
(Forum 2)
14:00 - 14:05Milda Babonaitė
(Department of Botany and Genetics, Institute of Biosciences, Vilnius University) LITHUANIA
Evaluation of Cytotoxicity and Genotoxicity of Nano-sized Plastic Particles
14:05 - 14:10Cynthia Recoules
Effect of cell treatment procedure on in vitro genotoxicity assessment
14:10 - 14:15Mojgan Najafzadeh
(University of Bradford) UK
A novel form of gallic acid to improve the compound bioavailability and cancer
14:15 - 14:20Alba Garcia-Rodriguez
(Universitat Autònoma de Barcelona) SPAIN
Drosophila melanogaster as bioindicator of microbiome dysfunction
14:20 - 14:25Kristyna Tomasova
(Biomedical Center, Faculty of Medicine in Pilsen, Charles University) CZECH REPUBLIC
A modified alkaline comet assay to measure base excision repair in mitochondria

14:30 – 16:00
Fritz Sobels & Early Career Awards

16:00 – 17:30
Poster Session 2 & Sponsor Visit
(while coffee is served)

17:30 – 18:30
EEMGS General Assembly

18:30 – 19:30
SEMA General Assembly

20:30 – 00:00
Congress Dinner

Session 10:
error-corrected Next-Generation Sequencing (ecNGS)
Thursday 18th May
9:00 - 11:00
(Forum 2)
Chairs: Vanessa Moraes de Andrade (Universidade do Extremo Sul Catarinense, BRAZIL) & Anthony Lynch (GSK, UK)
9:00 - 9:35Jiri Zavadil (Invited Speaker)
NGS and toxicogenomic signatures of human carcinogens
9:35 - 10:10Patrick van Eijk (Invited Speaker)
(Cardiff University) UK
NGS applications to assess vector mediated genotoxicity in genetic medicine
10:10 - 10:45Clint Valentine
(Twinstrand Bio) USA
Genomic Safety Assessment with ecNGS: The Next Generation
10:45 - 11:00Anthony Lynch
ecNGS analysis of induced mutagenesis in the low dose region. Case studies with noteworthy nitrosamines

11:00 – 11:30
Coffee Break

Session 11:
Advances In Regulatory Genotoxicology
Thursday 18th May
11:30 - 13:00
(Forum 1)
Chairs: Birgit Mertens (Sciensano, BELGIUM) & Antonio Guzmán (Alexion Pharmaceuticals, Inc., SPAIN)
11:30 - 12:15Marc Beal (Invited Speaker)
(Health Canada) CANADA
Modern in vitro screening tools to enhance quantitative chemical risk assessment
12:15 - 12:30Anouck Ingrid Thienpont
(Department of In Vitro Toxicology and Dermato-Cosmetology, Vrije Universiteit Brussel) BELGIUM
The GENOMARK transcriptomic biomarker demonstrates a high predictivity for genotoxic hazards and utility in potency ranking in human HepaRG™ cells
12:30 - 12:45Ann-Karin Olsen
(Norwegian Institute of Public Health, Division of Climate and Environmental Health) NORWAY
Assessing DNA damage in Testicular Germ Cells in the Comet Assay
12:45 - 13:00Michele Davigo
(National Institute for Public Health and the Environment (RIVM), Centre for Health Protection) THE NETHERLANDS
Assessing the DNA damage potential of cigarette and iQOS emissions in human bronchial epithelial cells
Session 12:
Human Biomonitoring
Thursday 18th May
11:30 - 13:00
(Forum 2)
Chairs: Stefano Bonassi (IRCCS San Raffaele Roma, ITALY) & Blanca Laffon (Universidade da Coruña, SPAIN)
11:30 - 12:00Gareth Jenkins (Invited Speaker)
(University of Swansea) UK
Understanding blood cell mutational biomarkers for biomonitoring and disease purposes
12:00 - 12:15Lucia Migliore
(University of Pisa) ITALY
The importance of gene – environment interactions in Alzheimer disease and the emerging role of epigenetics
12:15 - 12:30Vanessa Sousa
(University of Porto) PORTUGAL
Assessment of DNA damage in cumulus cells from infertile women using comet assay
12:30 - 12:45Soňa Vodenková
(Charles University) CZECH REPUBLIC
Association of mitochondrial DNA copy number and telomere length with colorectal cancer patient outcomes
12:45 - 13:00Mirta Milić
(Institute for Medical Research and Occupational Health) CROATIA
The use of combined different approaches in assessing the conditions and making prediction models in severely obese BMI ≥ 35 kg m-2 (FFQ, DII, anthropometric, biochemical and DNA damage parameters)

13:00 – 13:30
Closing Ceremony

HUMN Workshop

The buccal micronucleus (MN) cytome assay – New Horizons for its implementation in human biomonitoring and clinical studies

Michael Fenech (University of South Australia), Siegfried Knasmueller (Medical University of Vienna Institute of Cancer Research), Stefano Bonassi (San Raffaele University)

HUMN WorkshopThursday 18th May: 14:00 - 17:30
(Forum 2)
13:00 - 14:00Registration & Lunch
Early afternoon Session 14:00 - 15:40
14:00 - 14:10Welcome & Overview of Workshop Goals
Co-chairs: Michael Fenech (Genome Health Foundation, AUSTRALIA), Siegfried Knasmueller (Medical University of Vienna, AUSTRIA), Stefano Bonassi (IRCCS San Raffaele Roma, ITALY)
14:10 - 14:40The biology of buccal cells and the buccal micronucleus (MN) cytome assay
Claudia Bolognesi (Ospedale Policlinico San Martino, ITALY)
14:40 - 15:10Use of buccal cytome assays in the occupational exposure studies
Georg Wultsch (Medical University of Vienna, AUSTRIA)
15:10 - 15:40Association of buccal MN cytome assay biomarkers with disease and their relevance for clinical studies
Stefano Bonassi (IRCCS San Raffaele Roma, ITALY)
15:40 - 16:00Coffee Break
Late afternoon Session 16:00 - 17:30
16:00 - 16:30Impact of nutrition and life style on formation of micronuclei and other nuclear anomalies in buccal cells
Siegfried Knasmueller (Medical University of Vienna, AUSTRIA)
16:30 - 16:45Automation of the Buccal Micronucleus Cytome Assay
Michael Fenech (Genome Health Foundation, AUSTRALIA)
16:45 - 17:00Artificial Intelligence in Microscope-Based Imaging: Automation of the Buccal Micronucleus Cytome Assay?
Christian Schunck (MetaSystems, GERMANY)
17:00 - 17:30Discussion on knowledge gaps regarding the buccal MN cytome assay and a roadmap for its translation into practice
(open to all participants)
Share This